Antibodies may help immune system kill flu by keeping virus from
hiding in cells, research shows
It may be far from your mind in the mid-summer heat, with beaches full of sunbathers — but researchers in Jerusalem have developed antibodies that may boost the body’s resistance to the winter flu. The antibodies – proteins that fight disease – may help the immune system eliminate influenza by interfering with the ability of the virus to hide in the body’s cells, the researchers found. Recently published in the journal Science, the findings could point the way to more effective flu-fighting drugs. “Altogether, the novel antibodies we have developed will allow our immune system to respond more efficiently to a wide variety of influenza infections,” said Yotam Bar-On, a doctoral candidate in immunology and cancer research, who led the study under Prof. Ofer Mandelboim at The Hebrew University of Jerusalem. The flu is a major global health problem. Seasonal epidemics, which typically peak in the weeks after the New Year, result in up to about 5 million serious infections and about 500,000 deaths annually. In the United States, flu epidemics result in some 3.1 million days in the hospital and an average of $10.5 billion in direct medical costs every year. “It is thus urgent to develop new drugs for fighting influenza infection, which requires an understanding of the virus’s life cycle and its interaction with the host’s immune system,” said Bar-On. The body has its own ways of battling the flu. Natural killer cells, which are part of the immune system, have been shown to be capable of eliminating flu-infected cells.