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The Democratic-controlled U.S. Senate on Wednesday approved a Republican measure that would overturn President Joe Biden’s COVID-19 vaccine-or-test mandate for private businesses, with two Democrats joining Republicans to back the initiative.

The 52-48 vote sends the legislation to the Democratic-led House of Representatives, where it faces strong headwinds, while Biden has threatened to veto it.

The legislation would overturn administration rules ordering businesses with 100 workers or more to require vaccinations or coronavirus testing for millions of employees.

The measure was not subject to Senate rules that require 60 of its 100 members to agree on most legislation, meaning it could pass with just a 51-vote simple majority. Two Senate Democrats – Joe Manchin and Jon Tester – joined 50 Republicans in voting for the bill.

The initiative underscores the intense political opposition facing administration efforts to combat COVID-19 at a time when health officials are trying to contain the highly contagious Omicron variant.

Republicans have said they were inundated with calls from businesses with up to 500 workers that are concerned about having to fire employees who oppose COVID-19 vaccines and testing.

“It’s got Main Street America scared,” Republican Senator Mike Braun, who was spearheading the legislative drive, said before the Senate vote.

The White House said in a statement on Tuesday that employers would face no burden from the mandate because the vast majority of American adults are fully vaccinated and noted that the rule exempts small businesses.

Biden’s private business mandate has already been put on hold by a federal appeals court https://www.reuters.com/world/us/federal-appeals-court-affirms-stay-biden-vaccine-mandate-2021-11-12. A U.S. judge https://www.reuters.com/legal/litigation/us-judge-blocks-last-remaining-biden-admin-covid-19-vaccine-rule-2021-12-07 in Georgia also blocked a Biden vaccine mandate aimed at federal contractors on Tuesday.

“We are in the middle of a public health crisis. Everyone sees the damage it causes,” Senate Majority Leader Chuck Schumer, the top Democrat, said in a speech. “The way to solve this is to be driven by science.”

The United States has the world’s highest daily average of new coronavirus infections. The virus has infected 49.5 million Americans and killed more than 794,000, the highest death toll of any country, according to the Reuters COVID-19 Tracker.

Republicans touted the measure’s bipartisan support as a clear message of public concern about the mandate’s potential impact on workers, businesses and the economy.

The chamber’s top Republican, Mitch McConnell, branded the Biden mandate as an “illegal” and “absurd” government effort to micromanage the lives of private citizens.

“This is not how things work in our country, period,” McConnell said.