Heart attacks are one of the most common and deadly human ailments, with a cardiovascular event striking once every 34 seconds in the United States. Yet few know that following a heart attack, a good portion of the heart muscles remain damaged, leaving patients at risk for future heart failure and other serious cardiovascular diseases. And despite the brevity of most cardiovascular events, human heart cells rarely regenerate (unlike blood, hair and skin cells), which led researchers at the Weizmann Institute in Israel to question whether heart cells can be programmed to reverse damage in the heart.
Prof. Eldad Tzahor and Dr. Gabriele D’Uva succeeded in both understanding why heart cells don’t regenerate in repairing damaged heart muscles in mice. These insights may be key in formulating a treatment for heart conditions related to and following heart attacks, that is if the researchers succeed in regenerating heart cells in human subjects as well.