RUTHFULLY YOURS

https://www.aol.com/lifestyle/synthetic-molecule-targets-kills-breast-000700149.html

Scientists have developed a new molecule that can deliver powerful immune-activating treatment directly to cancer cells, marking an important advancement in cancer therapy. Traditionally, one major obstacle in fighting cancer is overcoming the tumor’s ability to suppress the body’s immune response.

Now, researchers at Stanford University have created an innovative treatment capable of turning immunologically inactive tumors into targets the immune system can attack.

A Novel Approach to Immunotherapy

Current cancer treatments often involve injecting immune-activating substances directly into tumors. However, not all cancers are easily reachable. To overcome this challenge, the Stanford team combined two crucial elements into a single synthetic molecule, PIP-CpG. One part of the molecule, PIP, identifies and binds specifically to integrins—proteins commonly found on cancer cells. The other part, CpG, acts as an immunostimulant by activating Toll-like receptor 9 (TLR9).

Idit Sagiv-Barfi  and Ronald Levy  pioneered a potential cancer therapy by injecting two immune-boosting agents directly into solid tumors. 

When administered intravenously, the innovative PIP-CpG molecule efficiently reaches multiple cancer sites throughout the body. By directly targeting tumor sites, this treatment ensures that the immune-stimulating drug accumulates precisely where it’s needed most.

Effective Tumor Targeting and Immune Activation

The research team tested this therapy in mice suffering from aggressive breast cancer. After receiving just three doses, six out of nine mice survived significantly longer than untreated mice. Even more promisingly, three of these mice appeared completely cured, showing no tumor recurrence over several months. Impressively, a single dose was sufficient for complete tumor elimination in half of the tested mice.

Jennifer Cochran, PhD, Shriram Chair of the Department of Bioengineering at Stanford, was enthusiastic about these remarkable results. “We essentially cured some animals with just a few injections,” she said. “It was pretty astonishing.”

When researchers examined the treated tumors, they observed a drastic transformation. Previously dominated by cells suppressing immune activity, the tumors became filled with activated immune cells, including CD8+ T cells, CD4+ T cells, and B cells. This shift mirrors the results usually seen only with direct tumor injections.

Overcoming Limitations of Previous Therapies

https://pjmedia.com/benbartee/2025/06/27/rfk-jr-axes-all-funding-for-bill-gates-global-vaccine-alliance-n4941219

Whereas the general modus operandi in legacy media is to smear RFK Jr. as an “anti-vaxxer” within the first sentence, the Washington Post courteously waited until the second paragraph to label RFK Jr. a “vaccine misinformation” spreader on its way to condemning him for cutting federal funding to Bill Gates’ global “vaccine alliance,” GAVI.

Via Washington Post (emphasis added):

The United States will halt its contributions to Gavi, the global alliance that works to expand access to vaccines for children in some of the world’s poorest countries, said Health and Human Services Secretary Robert F. Kennedy Jr. Wednesday — a move that public health experts said would have deadly consequences.

Kennedy, who has a history of spreading vaccine misinformation, announced the decision in video remarks made to a Gavi summit in Brussels, during which he accused the group of neglecting “the key issue of vaccine safety.”…

In his remarks, Kennedy cited a study linking the DTP vaccine — for diphtheria,a highly contagious bacterial infection that kills 5 to 10 percent of those affected, as well as tetanus and pertussis — to increased child mortality. Kennedy also said Gavi should “consider the best science available,” and “re-earn the public trust.”

The Bezos paper didn’t actually cite or quote the DTP study referenced by Kennedy, so I went and found it.

https://www.city-journal.org/article/mental-illness-certified-community-behavioral-health-clinics-funding-grants

The Department of Justice is brainstorming ways to clear homeless encampments and increase involuntary hospitalization, focusing on people with serious mental illness. Fortunately, the federal government already has a resource for people with such conditions: Certified Community Behavioral Health Clinics. CCBHCs serve as one-stop shops for people with serious mental illness, providing coordinated physical and specialty behavioral health services. As part of their congressional mandate, the clinics turn no one away, regardless of ability to pay. 

But according to an April 10 document leaked to the media, the White House was considering defunding grants for the CCBHC program. This would have eliminated a crucial lifeline for the seriously mentally ill. 

CCBHCs have been a bipartisan effort. In 2014, Congress and President Obama established the clinics under an eight-state Medicaid demonstration project that launched three years later. In 2020, Congress and President Trump adopted the CARES Act, which expanded the demonstration and provided grant funding for additional CCBHCs. Today, nearly 500 CCBHCs serve 3 million patients across 46 states.

https://issuesinsights.com/2025/05/19/medicaid-end-it-dont-mend-it/

As soon as Republicans mentioned cutting spending on Medicaid as part of their “reconciliation” bill, the usual suspects started rolling out their standard talking points. They’re cutting health care for the poor to pay for tax cuts for the rich! Millions will lose coverage! The disabled will suffer! Oh, the humanity!

Well, if the GOP is going to be accused of destroying Medicaid when all they are proposing is a minor haircut, why not go all out and scrap this hopelessly flawed, fraud-riddled, budget-busting disaster of a program and start over from scratch?

First, let’s dispense with the claim of “devastating” cuts to Medicaid. The House reconciliation bill would reduce Medicaid spending by $625 billion. That might sound like a lot, but it’s stretched out over 10 years, at a time when Medicaid is on track to spend $8.6 trillion. Medicaid spending will still go up every year under the House bill, just a tiny bit more slowly.

What Republicans should really be talking about is giving Medicaid the USAID treatment. Shut it down and start over from scratch.

Let’s line up the reasons.

It was sold on a lie. The original claim made in the mid-1960s was that the federal government and the states would split the cost of Medicaid. But that happened only once: in the program’s first year. Ever since, the federal share has grown while the states’ shares have shrunk. By 2005, states were paying only 42% of Medicaid’s bills. In 2022, the state share dipped below 30%.

Over the past 60 years, states have pressured federal lawmakers to make a multitude of exceptions to the 50-50 split, which lawmakers were only too happy to provide because there is no cap on federal Medicaid spending.

https://www.city-journal.org/article/marijuana-legalization-weed-mental-illness-health

America’s ongoing marijuana-legalization experiment will have many consequences. That goes especially for the seriously mentally ill, a sliver of the adult population but overrepresented among the ranks of compulsive pot users. Treating schizophrenia and bipolar disorder is never easy; even when treatment is available, the seriously mentally ill often fail to comply. A schizophrenic who spends most of his days in a dark room smoking weed is not a clinically promising case.

Modern mental-health systems are community-based and thus shaped by community norms. Decades ago, clouds of pot smoke were not often encountered on city streets. Now that they’re ubiquitous, a seriously mentally ill individual may be inclined to wonder what’s so objectionable about an activity that normal Americans do daily, in public and even during working hours.

The issue is only partly whether pot causes mental illness. A large body of research studies, involving tens of thousands of people, has suggested, with impressive replicability, that heavy cannabis use increases the risk of developing mental illness. Legalization proponents reject this, contending that, while the rate of marijuana consumption has soared over recent decades, the rate of serious mental illness seems to have stayed flat.

But this debate has eclipsed interest in the effect of continued cannabis use on those already mentally ill. What can be done about that? For scores of clinicians and families of the mentally ill across the nation, it’s the more pressing question.

In recent years, countless family memoirs and nonfiction accounts of mental illness have extensively chronicled the descent into madness. This literature often highlights marijuana more than any other intoxicating substance. Pot plays a notable role in several recent book-length treatments of mental illness, including Randye Kaye’s Ben Behind His Voices (2011), Patrick and Henry Cockburn’s Henry’s Demons (2011), Paul Gionfriddo’s Losing Tim (2014), Mindy Greiling’s Fix What You Can (2020), Miriam Feldman’s He Came in With It (2020), Meg Kissinger’s While You Were Out (2023), and Jonathan Rosen’s The Best Minds (2023).

https://www.msn.com/en-us/health/other/trump-s-nih-chief-lets-loose-on-fauci-vaccines-and-covid-cover-ups/ar-AA1EKMUX

Jay Bhattacharya is no longer on the fringe.

When the Covid-19 pandemic hit, the then-Stanford professor was one of the loudest critics of lockdowns, school closures and what he called “utopian” public health planning, and he was often dismissed by mainstream public health officials.

Five years later and Bhattacharya is now the director of the National Institutes of Health, one of the most powerful figures in public health and biomedical research in the U.S. and across the globe. He oversees a budget in the tens of billions and helps determine who gets funded — and whose ideas get left behind.

“The first and most important thing,” he says in a new interview with POLITICO Magazine, “is that dissenting voices need to be heard and allowed.”

In a wide-ranging conversation, Bhattacharya laid out his vision for American science under President Donald Trump and discussed the ongoing fallout from the pandemic. In particular:

He praises the pardon of Anthony Fauci even as he effectively accuses the former public health official of engaging in a Covid cover-up.
He endorses the creation of an independent commission to assess the pandemic response.
He rejects the continued recommendation of mRNA vaccines for healthy young people — and says he himself has received just two doses, both in 2021.
He explains why he thinks it’s unlikely vaccines cause autism — but that he won’t prejudge the issue.
 He waves off the notion that Europe would be able to poach American scientists amid Trump’s war on elite universities. “France is a nice place to visit,” he scoffs.

This interview has been edited for length and clarity.HHh