https://www.wsj.com/articles/another-promising-vaccine-this-one-from-johnson-johnson-11612131877?mod=opinion_lead_pos7
Some good news this week: Johnson & Johnson’s vaccine looks likely to become the third U.S. Covid-19 vaccine to enter the market. The company released data this week showing the vaccine is about 70% effective against the virus, and its version requires only one shot. The Food and Drug Administration will need to review the evidence thoroughly, but the preliminary data is promising. The company is collecting more information to determine whether a booster shot could provide even better protection.
Crushing Covid will require making the most of the different vaccine candidates, which come with their own pros and cons, and tweaking them to stay ahead of viral mutations. The vaccines all follow a similar basic approach, putting into arms the spike protein found on the surface of the coronavirus. But Johnson & Johnson’s vaccine takes a slightly different approach to delivery than vaccines produced by Pfizer and Moderna. (I am on the board of Pfizer.) The biotech company Novavax is pursuing a vaccine candidate with its own special delivery system. All four might be available by the summer, which would mean an ample supply.
Americans will wonder which one works best? It will be tempting to compare data across trials. But that isn’t apples to apples; the vaccines and the data aren’t all the same. And new variants of Covid may demand vaccines that offer slightly different layers of protection and target slightly different parts of the virus.
The regulatory process must encourage this kind of portfolio diversification, while allowing tweaks to keep ahead of the virus’s twists and turns. The FDA is working on guidance to address new variants, which will include a pathway for updating vaccines.