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ISRAEL

10 Toxic Terms Pro-Israel Aadvocates Must Fight :The phrases we must stop repeating. Lee Bender and Jerome Verlin *****

Mainstream Western media coverage of Israel is laced with expressions intentionally crafted to delegitimize the Jewish State. The good news is that these terms weren’t written in stone 3,300 years ago, but are post-Israel independence creations. By forfeiting this language, we forfeit our history. Here are 10 phrases we must stop repeating:

#1- “The West Bank” – No, it’s not. “Judea and Samaria” are not just “biblical names,” but the names the hill country of Israel was known by from ancient times, including in the U.N.’s 1947 partition resolution, until after Transjordan invaded in 1948 (and was ousted by Israel in 1967) and named it such to disassociate its inherent Jewish connection.

#2 – “East” or “traditionally Arab East” Jerusalem: Jerusalem has been the capital of three homeland states, all Jewish, in the past 3,000 years, and has had a renewed Jewish majority since 1800’s Ottoman rule. Palestinian Arabs have never ruled any part of Jerusalem. There was no such place as “East” Jerusalem until invading Jordan seized the historical heart of the city in 1948 and expelled its Jews; until then it had never been a divided city. The eastern section of the city is where the Old City, Jewish Quarter, Temple Mount, Mount of Olives cemetery, Christian Quarter and Church of the Holy Sepulcre are located. Jerusalem is Judaism’s holiest city; it is not holy to Muslims and is not mentioned once in the Qu’ran. Only since Israel reunified the city has there been equal rights and access to religious sites of all faiths. Say rather: Jerusalem, period

#3 – “The UN sought to create Jewish and Palestinian States:” It did not. Over and over in its 1947 partition resolution, the UN referenced “the Jewish State” and “the Arab” [not “Palestinian”] State. There are 22 independent Arab states.

#4– “Palestinian Refugees of the War that Followed Israel’s Creation,” or the “Palestinian Refugee Issue:” This suggests that an indigenous population of Arab “Palestinians” was unilaterally displaced by the 1948 five-Arab-state- army invasion for Israel’s destruction, which encouraged and ordered local Arabs to leave. Much forgotten is that more Jews were consequently expelled from vast Arab lands they had lived in for many centuries (850,000- 900,000) than Arabs left tiny Israel (500,000- 650,000).

#5 – Israel “Seized” Arab Lands in 1967: It did not. Israel captured these territories in a defensive war from Arabs who vowed to destroy her. Israel has greater historic legal claims and rights to these lands.

#6 – Israel’s “1967 Borders:” The 1949 Israel-Jordan Armistice Agreement expressly declared the “green line” it drew between the two sides’ ceasefire positions as a military ceasefire line only, and not a political border. The post-’67 war U.N. Resolution 242 pointedly does not demand Israel retreat from these lines.

#7 – “Israeli-Occupied West Bank and East Jerusalem:” No. The 1920 League of Nations Palestine Mandate recognized the Jewish people’s right to reconstitute its Jewish National Home in Palestine (including Judea and Samaria, and what ultimately became Jordan), and called for close settlement of the Jews on this land, where Jews have continuously lived, claiming it as their homeland, for three thousand years. At worst, the legal status is disputed, not “occupied” or “Palestinian” territories.

#8 – “Jewish Settlers and Settlements” vs. “Palestinian Residents of Neighborhoods and Villages:” Jews are not alien “settlers” implying “occupiers” in a Jerusalem that’s had a Jewish majority since mid-19th century or in the Judea-Samaria Jewish historical heartland. Israelis living there are residents who live in cities, towns and villages.

#9 – “Palestinians accept and Israel rejects a Two-State Solution:” Wrong on both counts. The U.S. and Israel define “Two States” as two states for two peoples – Jews and Arabs. Many Israelis, including Prime Minister Netanyahu, support that plan – conditioned on an end to Palestinian terror. The Arabs have rejected a Palestinian Arab state living side-by-side with a Jewish state five times since 1937, and continuously deny Israel’s right to exist no matter where its borders are drawn.

#10 – “The Palestinians:” During the Mandate, “Palestinian” typically referred to Palestine’s Jews. The UN’s 1947 partition resolution called Palestine’s Jews and its Arabs “the two Palestinian peoples.” Palestinian Arabs – ancestrally, culturally, linguistically and religiously are akin to neighboring regional Arabs – began claiming exclusive “Palestinian peoplehood” only in the 1960s. Post-1967 war UN resolution 242 does not mention “Palestinians.” Most Palestinian Arabs cannot trace their own lineage to the land back more than 4 generations.

Lee Bender is the co-President, and Jerome Verlin is the co-Vice Present of the Zionist Organization of America-Greater Philadelphia District, and they are the co-authors of the book “Pressing Israel: Media Bias Exposed From A-Z” (Pavilion Press and co-developers of the website and mobile app, www.factsonIsrael.com.

Netanyahu Pushes New West Bank Settlement Construction is intended to house families evicted from Amona outpost By Rory Jones and Felicia Schwartz

Israel’s Prime Minister Benjamin Netanyahu on Thursday proposed the first new settlement in decades in the West Bank as Israeli officials and the White House appear to have reached an understanding on future settlement construction.

The new settlement will be built to accommodate roughly 40 families—about 300 residents— evicted in February from a settlement outpost called Amona, Mr. Netanyahu’s office said. The move needs to be confirmed by the Israeli cabinet, his office said.

The announcement comes as U.S. and Israeli officials in recent weeks have conducted talks on limiting settlement construction in the West Bank after President Donald Trump asked Israel to hold off.

The Trump administration gave the new settlement tacit approval on Thursday, by refraining from condemning the settlement construction, as past Democratic and Republican administrations have done.

A White House official said the Trump administration has made clear that “further unrestrained settlement activity does not help advance peace” and welcomed Israel’s commitments to consider U.S. concerns about settlements in the future.

“With regards to the new settlement for Amona residents, we would note that the Israeli Prime Minister made a commitment to the Amona settlers prior to President Trump laying out his expectations, and has consistently indicated that he intended to move forward with this plan,” the official said.

The talks between the U.S. and Israel have aimed at creating the conditions to get Israelis and Palestinians back to the negotiating table on a future peace deal, according to U.S. and Israeli officials.

The U.S. on Thursday called on Israelis and Palestinians to take “reasonable actions moving forward that create a climate that is conducive to peace” and said it would continue to work with the parties and regional powers. CONTINUE AT SITE

Israelis develop a blood test to diagnose lung cancer by Dr. Itay Gal

Lung cancer is one of the most violent types of cancer, responsible for the death of 1.6 million patients each year; a first of its kind blood test, developed in Israel, succeeds in diagnosing the cancer long before it spreads in the body.

The new test is able to diagnose the disease long before it spreads in the body, thus increasing the chance of survival, as many patients usually die within a few months of the diagnosis.

Each year, approximately 1.8 million new lung cancer patients are diagnosed, a 1.59 million of whom will die within the first year post-diagnosis. Most cases are discovered by chance, after a screening test, or due to abnormal symptoms such as prolonged cough, bloody cough, breathing difficulties or weight loss.

Diagnosis of the disease is usually done via a CT scan, but its level of accuracy is not high, and in 25 percent of the cases, the lung scan shows lesions of which only 3% are indeed cancerous.

The new test was developed by Dr. Elon Ganor, CEO of Nucleix, in collaboration with his colleagues Dr. Danny Frumkin, Dr. Adam Wasserstrom and Dr. Ofer Shapira. The test is based on the genetic characterization of cancer.

Cytosine is one of the four main bases found in DNA and it is held together by three hydrogen bonds.

A study by Prof. Haim Cedar from the Hebrew University of Jerusalem found that the three hydrogen bonds molecule serves as a kind of on/off switch that activates (or deactivates) different genes and has a decisive effect on our susceptibility to cancer and other diseases. When a certain change occurs on the same molecule, a wild division of uncontrolled cells begins, resulting in the formation of cancerous tumors.

The Israeli researchers were able to isolate the specific change on that three-bonds molecule and designed a unique blood test that identifies it. To examine the efficacy of the development, two studies were conducted, involving 170 volunteers in each study: 70 were lung cancer patients and 100 were healthy, but belonged to groups at high risk for lung cancer, such as heavy smokers.

The results showed a specificity of 94% (i.e., 94% of the healthy subjects were indeed identified as healthy), and a sensitivity of 75% (i.e., 75% of the patients were indeed identified as diseased). This is a very high level of accuracy.

Connecting the Middle East dots Ambassador (Ret.) Yoram Ettinger

Video#39: http://bit.ly/2mT25Ri; Entire mini-seminar: http://bit.ly/1ze66dS

According to the Saudi Arabian-based newspaper, Arab News, “the Arab Spring is not about seeking democracy, it is about Arabs killing Arabs… about hate and sectarian violence…. The Arab Spring is an accumulation of years of political corruption, human rights violations, sectarianism and poor education systems…. The Arabs were never united and are now divided beyond anybody’s imagination. Arabs hate each other more than they hate the outside enemy. Syrians are hurting Syrians and the Israelis are the ones who treat the Syrian wounds [in an Israeli field hospital built on the Golan Height].”

2. Connecting the dots of the increasingly boiling Arab Street highlights the 1,400 year reality of intense intra-Arab violent intolerance, hate education, transient (one-bullet) regimes, tenuous policies, non-compliance with intra-Arab agreements, explosive unpredictability and the absence of intra-Arab peaceful coexistence.

3. Since the 7th century appearance of Islam, the Arab street has never experienced freedom of religion, speech, press, association or movement, which are prerequisites for free elections and peaceful coexistence. Arab societies are ruled by – and the will of the majority is subjugated by – non-democratic, minority rogue regimes.

4. The Arab Street is dominated by domestic, regional, national and intra-Arab subversion and terrorism. Ethnic cleansing in Syria, Iraq, Yemen, Tunisia, the Sudan and Libya reflects the lack of national cohesion on the Arab street and the merciless intra-Arab/Muslim fragmentation along ethnic, tribal, cultural, geographic, ideological and religious lines. The misperception of the national cohesion of two of the most powerful Arab countries throughout the 20thcentury – Iraq and Syria – has collapsed, setting them on a chaotic course of disintegration. Studying the fate of minorities in Arab countries, reveals the devastating Arab/Muslim attitude towards the “infidel” Christians, Jews, Hindus or Buddhists.

5. The current increasingly, turbulent Arab Tsunami, which erupted in 2010, has intensified anxiety and panic among the pro-US regimes of Egypt, Jordan, Saudi Arabia, Kuwait, the United Arab Emirates, Oman, and Bahrain, which are inherently susceptible to domestic upheaval. They are aware that Egypt’s Mubarak, Libya’s Kaddafi, Tunisia’s Ben Ali and Yemen’s Salah (possibly joined by Syria’s Assad) were perceived to be Rock of Gibraltar-like regimes, but were overthrown by Islamic mobs. They are cognizant of the clear, present and lethal threat posed by Iran and Iran’s adversary, ISIS (the “Islamic State in Iraq and Syria”). They are concerned about the lava erupting from the endemic civil war in an intractably fragmented Yemen, which controls the route of oil tankers from the Indian Ocean to the Mediterranean.

6. The December 2010 Tunisian upheaval fueled the February 2011 Libyan and Egyptian eruptions, which fed the February 2011 turmoil in Yemen and Bahrain, providing a tailwind for the March 2011 surge of the civil war in Syria. The intensification of terrorism and disintegration in Iraq poses an imminent deadly threat to the Hashemite regime in Jordan, which could be transformed into another haven for Islamic terrorism, threatening to sweep through Saudi Arabia and other pro-US Gulf states.

7. The increasingly boiling Arab Street accentuates Israel’s unique roleas the only stable, reliable, effective, democratic and unconditional national-security-producing-ally of the US, whose posture of deterrence – in the face of Islamic terrorism and Iran – is a life insurance policy for pro-US Arab regimes in the Middle East.

Germany Likes Guilty Jews Best

This piece was first published on the Hebrew-language website Mida on March 26, 2017 rendered into English by Avi Woolf, and republished here with permission. The original article can be found by clicking on the link at the bottom of this page.

At a time when the German government is cancelling its consultations with the Israeli government and assigning full blame to Israel for the conflict with the Palestinians, Mahmoud Abbas is being given the royal treatment in Berlin and even received the “Hope for Peace Award.”

Is it stupidity? Naïveté? An old ideology which has not disappeared from the world, or just a desire to advance various interests at any cost without regard for basic human values? The attitude of Germany and far too many Germans to what’s going on in the Middle East regularly leads to these questions, which only multiply with time. The more the situation and conditions in the Middle East become complicated, or one might say become clarified, the more Germany holds onto positions that are increasingly detached from reality, with no ability to carry out a sober, realistic analysis of those ideas.

This problematic approach primarily expresses itself when it comes to the Israeli-Arab conflict, which magnifies the inability of far too many Germans—especially decision makers and policy shapers—to use their rationality and reason. As soon as the name Israel is mentioned, too many Germans have a defensive reaction, an instinctive avoidance of being accused of past crimes, and then proceed on the principle that the best defense is a good offense. Thus has Israel automatically become in the eyes of most Germans, including senior public officials, the sole guilty party for all the problems in the Middle East—which have recently also invaded Europe and Germany.

This method of attack was primarily developed and honed by the Communist regime, which ruled East Germany until 1990. The Israelization of anti-Semitism, that is the clothing of anti-Semitism in anti-Israel and anti-Zionist garb, was an official policy in East Germany that did not disappear along with the regime. To the contrary: it became embedded within the general population of unified Germany, and became a very common mindset.

One could have expected that the disappointing developments of the Arab Spring regarding the possible democratization and liberalization of the Middle East, the collapse of the states around the region and their sinking into blood-soaked civil wars, and the arrival of Islamist terror on European soil—would seriously shake up the frozen way in which the German establishment and people think about the region and lead them to rethink their positions. But this change did not occur, and far too many Germans prefer to continue to hold on to their old and outdated view of the Middle East, in which Israel is the primary guilty party for all the region’s problems.

This is especially true in reference to right-wing Israel, which in the eyes of many Germans—who do not God forbid wish to be seen as anti-Semites—is putting itself on the road to self-destruction. Those same German are dead-set against having a serious discussion of the contents of the positions of the Israeli right. As far as they are concerned, only an Israeli withdrawal and the establishment of a Palestinian state as part of the “two-state solution” will heal the ills of the Middle East and bring world peace—perhaps much like the one they dreamed about in Communist East Germany. The fact that Israeli withdrawals, such as those done in Lebanon and the Gaza Strip, did not bring brotherhood in the Middle East any closer but actually drove it away, is also seen as Israel’s fault, since it wasn’t sufficiently diplomatically daring to acquiesce to all the Arabs’ demands.
“The Hope for Peace Award”

The recent visit to Germany by the Palestinian Authority president Mahmoud Abbas revealed the strangeness of German policy toward the Middle East, especially regarding the Arab-Israeli conflict. Germany, which sees itself as the guardian of democracy and protector of human rights, went out of its way to honor an Arab leader who was indeed chosen in free elections but who has not allowed any elections since 2005, is accused by his subjects of violating human rights and of corruption, has fled from making brave decisions to advance a peace agreement with Israel, is a Holocaust denier who continues to encourage violence against Jews under the cover of “resistance to the occupation,” has done nothing to stop the incitement to violence in the areas under his control, and refuses to recognize the Jewishness of the state of Israel—even though such recognition is the official policy of the German government. Mahmoud Abbas symbolizes everything Germany opposes, and yet it still gives him honors generally reserved for the world’s great leaders.

Two Netanyahus Meet Two Trumps by Rael Jean Isaac

One of the most widely accepted misconceptions concerning the Arab-Israel conflict (a subject awash in misconceptions) is that Prime Minister Benjamin Netanyahu is a “hard-core right winger.” There is nothing in his behavior as Prime Minister during his first years in that role (1997-99) or in his more recent period in office, beginning in 2009, to support this belief. On the contrary, like his predecessors, he has made repeated dramatic territorial and other concessions, including acceptance of the so-called “two state solution.”

In Jan. 1997, still in the first year of his first term, he signed the Hebron Protocol with the Palestine Authority, turning over most of Hebron, after Jerusalem the most important city in Jewish history, to the PA. Netanyahu did so little to change Labor’s disastrous post-Oslo policy that erstwhile supporter Benny Begin (Menachem’s son) derided him at a Likud Party meeting in March of that year. “Arafat releases terrorists and so does Israel. Arafat smuggles in weapons and we give him assault rifles to round off his stores….We have government offices in Jerusalem [supposedly the unified capital of Israel] and so do they.” The following year, under President Clinton’s prodding, Netanyahu signed the Wye River Memorandum in which he promised to turn over 40% of Judea and Samaria to Arafat, a safe corridor between these areas and Gaza, even an airport in Gaza. It is true Wye was not implemented, but that’s only because (predictably) Arafat promptly reneged on his commitments under the agreement.

That same year Netanyahu embarked on secret negotiations with Syria in which he offered to return the Golan Heights. Was Netanyahu prepared to go back to the 1967 border (which Clinton and Dennis Ross assert in their respective memoirs) or did Netanyahu, according to other reports, hold out for several kilometers beyond the international border line? Although Assad backed out, according to widespread reports in the Israeli press, in 2010 Netanyahu tried again, this time with Bashar Assad, offering to return to the June 4, 1967 lines. Fortunately the negotiations collapsed with the onset of the rebellion against the Syrian ruler. (One shudders to think what “success” would have meant for Israel, with Hezbollah and/or ISIS embedded on the shores of the Sea of Galilee.)

That near miss with disaster has not prevented Netanyahu from continuing to offer major concessions. In the wake of Obama’s Cairo speech, Netanyahu agreed to adopt the “two state solution” as his government’s policy. Moreover, retired Brigadier General Michael Herzog (brother of Israeli Labor Party head Yitzhak Herzog), who has participated in almost all Israel’s peace negotiations since Oslo in 1993, writes in The American Interest that Netanyahu in the Obama years offered such large withdrawals that he could not admit their scale to the Israeli public or his coalition partners.

And contrary to the widespread perception, fostered by the media, that Netanyahu has peppered the landscape of Judea and Samaria with Jewish settlements, Israel has not built a new settlement in 25 years. The much publicized on and off settlement freezes to which Netanyahu has agreed applied to existing communities, the “freezes” meaning there was no building even to accommodate natural population growth within them.

So what accounts for Netanyahu’s reputation as an unbudging hawk? The reason is that he knows better than he acts with the result that his rhetoric differs from his policies far more than has been the case with other Israeli leaders. Prime Minister Shimon Peres seems clearly to have believed in the mirage he concocted of a New Middle East. Prime Minister Olmert appears to have genuinely felt the emotions which in 2005 (in a speech to the Israel Policy Forum) he attributed to the people of Israel as a whole: “We are tired of fighting; we are tired of being courageous; we are tired of winning; we are tired of defeating our enemies.”

Israel Has Made Enough Sacrifices By Dan Calic

One of the oft-repeated laments from many world leaders when speaking about the long-festering Arab-Israeli conflict is regarding sacrifices.

How many times did former U.S. secretary of state John Kerry, former president Obama, or other leaders talk about the need for both sides to make sacrifices for peace? We’ve heard it repeatedly. Yet the truth of the matter is that only one side has made sacrifices, while the other side has not made any. One side has continuously demonstrated its desire for peace, while the other side has continuously demonstrated it wants the other destroyed.

The Arab population makes up over 98% of the Middle East, while geographically covers more than 99% of the land compared to the size of Israel. These facts are merely to provide some perspective. Yet despite of the overwhelming advantage the Arab world enjoys, the tiny Jewish nation of Israel is considered intolerable by many.

List of Jewish Sacrifices

1. In June 1967, Israel was forced to defend itself against Syria, Jordan, and Egypt in the Six-Day War. During this decisive Israeli victory the Holy Old City of Jerusalem was captured from the Jordanians, who had been in control of it since the Independence war ended in 1949. The victory reunited the Jewish people with Temple Mount and the Western Wall of the Second Temple compound. Israeli flags flew over their holiest site for the first time in modern history.

Yet, at the conclusion of the war, Defense Minister Moshe Dayan made a huge sacrifice in the interest of peace by awarding administrative control of Temple Mount to the Jordanian Waqf (Islamic Trust). He ordered Israeli flags removed and he banned Jews from praying on Temple Mount. This remains in effect today. In spite of Israel’s sacrifice Temple Mount remains a flashpoint issue and numerous riots have taken place at Al Aqsa mosque.

In the same war Israel captured the Gaza Strip and virtually all of the Sinai Desert.

David Friedman Sworn In as U.S. Ambassador to Israel Vice president says nomination shows ‘America stands with Israel’

WASHINGTON—President Donald Trump gained his first ambassador Wednesday when attorney David Friedman was sworn in as America’s envoy to Israel.

Vice President Mike Pence administered the oath of office to Mr. Friedman and hailed Mr. Trump’s decision to nominate his former bankruptcy attorney for the sensitive diplomatic post as “one of the clearest signs” of the president’s commitment to the state of Israel and the Jewish people.

“If the world knows nothing else, the world will know this: America stands with Israel,” Mr. Pence said as Mr. Friedman’s wife, Tammy, their five children and most of their grandchildren watched. Ron Dermer, Israel’s ambassador to the U.S., also attended the ceremony.
Mr. Friedman, whose nomination faced resistance from Democrats and some Jewish groups, said he was “humbled” by the trust Mr. Trump had placed in him. He also noted his standing as the first of Mr. Trump’s ambassador nominees to win Senate confirmation and be sworn in to office.

“Those facts speak volumes about how highly the Trump-Pence administration prioritizes our unbreakable bond with the state of Israel,” Mr. Friedman said.

He said he recently resigned from the law firm in which he was a founding partner.

The Senate approved Mr. Friedman’s nomination last week by a vote of 52-46, largely along party lines.
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Palestinians: We Have the Right to Poison the Minds of our Children by Bassam Tawil

They Palestinian Authority (PA) and Hamas wish to continue teaching children that the conflict with Israel is not over a two-state solution, but the “liberation of Palestine, from the river to the sea,” which means the annihilation of Israel. The goal is for the students to believe that Israel is one big settlement that has no place in the Middle East.

Along with Hamas, Abbas and his PA plan to continue inculcating Palestinian children with the idea that they should look to terrorists who kill Jews as their role models. It might be illuminating if the conversation between Trump and Abbas were to be informed by these uncomfortable facts.

In an ironic turnaround, the United Nations Relief and Works Agency for Palestinian Refugees (UNRWA) is now the object of intimidation and threats made by many Palestinians.

UNRWA is reportedly planning to introduce some changes to the curriculum in its schools in the West Bank and Gaza Strip, and the Palestinians are rather unhappy about it. They claim that UNRWA has “succumbed” to Israeli pressure to make the changes.

The proposed changes are based on leaks to Palestinians and have not been confirmed by UNRWA. Palestinians claim that they learned about the plans to introduce the changes during meetings with senior UNRWA officials.

According to the Palestinians, the changes are intended to “eradicate” their “national identity” and “history” and distort their “struggle” against Israel.

The Palestinians claim that the new textbooks have replaced the map of “historic Palestine” (including Israel) with pictures of a pumpkin and a bird. Palestinian textbooks often feature maps of “historic Palestine” without Israel. Cities inside Israel, such as Haifa, Jaffa, Tiberias and Ramle, are referred to as “Palestinian cities.” The Palestinian Authority (PA) media also refer to these cities as “Palestinian cities inside the 1948 Land.”

Israeli Scientists Find Mechanism That Causes Cancer Cells to Self-Destruct Hana Levi Julian

Israeli scientists have made an enormous discovery that can help lead
to a new treatment for at least two of the most resistant cancers that
exist: pancreatic and triple negative breast cancer.

Many cancer patients struggle with the adverse effects of
chemotherapy, still the most prescribed cancer treatment. For patients
with pancreatic cancer and other aggressive cancers, the forecast is
more grim: there is no known effective therapy.

A new Tel Aviv University study published last month in Oncotarget
discloses the role of three proteins in killing fast-duplicating
cancer cells while they’re dividing. The research, led by Prof. Malka
Cohen-Armon of TAU’s Sackler School of Medicine, finds that these
proteins can be specifically modified during the division process —
mitosis — to unleash an inherent “death mechanism” that
self-eradicates duplicating cancer cells.

“The discovery of an exclusive mechanism that kills cancer cells
without impairing healthy cells, and the fact that this mechanism
works on a variety of rapidly proliferating human cancer cells, is
very exciting,” Prof. Cohen-Armon said. “According to the mechanism we
discovered, the faster cancer cells proliferate, the faster and more
efficiently they will be eradicated. The mechanism unleashed during
mitosis may be suitable for treating aggressive cancers that are
unaffected by traditional chemotherapy.

“Our experiments in cell cultures tested a variety of incurable human
cancer types — breast, lung, ovary, colon, pancreas, blood, brain,”
Prof. Cohen-Armon continued. “This discovery impacts existing cancer
research by identifying a new specific target mechanism that
exclusively and rapidly eradicates cancer cells without damaging
normally proliferating human cells.”

The research was conducted in collaboration with Prof. Shai Izraeli
and Dr. Talia Golan of the Cancer Research Center at Sheba Medical
Center, Tel Hashomer, and Prof. Tamar Peretz, head of the Sharett
Institute of Oncology at Hadassah Medical Center, Ein Kerem.

A new target for cancer research

The newly-discovered mechanism involves the modification of specific
proteins that affect the construction and stability of the spindle,
the microtubular structure that prepares duplicated chromosomes for
segregation into “daughter” cells during cell division.

The researchers found that certain compounds called Phenanthridine
derivatives were able to impair the activity of these proteins, which
can distort the spindle structure and prevent the segregation of
chromosomes. Once the proteins were modified, the cell was prevented
from splitting, and this induced the cell’s rapid self-destruction.

“The mechanism we identified during the mitosis of cancer cells is
specifically targeted by the Phenanthridine derivatives we tested,”
Prof. Cohen-Armon said. “However, a variety of additional drugs that
also modify these specific proteins may now be developed for cancer
cell self-destruction during cell division. The faster the cancer
cells proliferate, the more quickly they are expected to die.”