https://www.wsj.com/articles/cdc-oversells-the-bivalent-covid-shot-hospitalizations-vaccine-booster-omicron-pandemic-pfizer-moderna-china-illness-death-11663793472?mod=opinion_lead_pos7
The Centers for Disease Control and Prevention recommends that everyone over 12 receive a “bivalent” Covid-19 vaccine as a booster dose. But only a select group are likely to benefit, and the evidence to date doesn’t support the view that a bivalent vaccine containing omicron or its subvariants is better than the monovalent vaccine. The CDC risks eroding the public’s trust by overselling the new shot.
The existing Pfizer and Moderna mRNA vaccines were designed to protect against the original strain of the novel coronavirus, known as Wuhan-1. The strain that left China, however, was D614G, the first variant. Between January 2020 and December 2021, D614G was replaced by the alpha variant then the delta variant. At the end of 2021, Oxford conducted a study to determine whether the mRNA vaccines still provided protection against severe illness and death caused by the variants. They did.
Then things changed. At the end of 2021, the omicron variant (BA.1) and its subvariants (BA.2, BA.3, BA.4 and BA.5) supplanted delta. Not only was omicron more contagious than delta; it also evaded immunity. Even the fully vaccinated were at risk of mild illness, and some of severe illness. A third dose was recommended, then a fourth. The CDC found that both a third and fourth dose reduced hospitalizations.
But not everyone benefited. Those who did fell into three groups: the elderly, people with serious health problems and people who were immunocompromised. As the CDC launches its fall booster dose campaign, it would be wise to focus on those at risk rather than the young and healthy.