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MEDICINE AND HEALTH

The untold story of the Human Genome Project: How one man’s DNA became a pillar of genetics By Ashley Smart —

https://www.statnews.com/2024/07/09/human-genome-project-untold-story-how-single-volunteer-became-genetics-foundation/?utm_source=pocket-newtab-en-us

STAT is co-publishing this investigation by Undark.

They numbered 20 in all — 10 men and 10 women who came to a sprawling medical campus in downtown Buffalo, N.Y., to volunteer for what a news report had billed as “the world’s biggest science project.”

It was the spring of 1997, and the Human Genome Project, an ambitious attempt to read and map a human genetic code in its entirety, was building momentum. The project’s scientists had refined techniques to read out the chemical sequences — the series of As, Cs, Ts, and Gs — that encode the building blocks of life. Now, the researchers just needed suitable human DNA to work with. More exactly, they needed DNA from ordinary people willing to have their genetic information published for the world to see. The volunteers who showed up at Buffalo’s Roswell Park Cancer Institute had come to answer the call.

To take part in the study was to assume risks that were hard to calculate or predict. If the volunteers were publicly outed, project scientists told them, they might be contacted by the media or by critics of genetic research — of whom there were many. If the published sequences revealed a worrisome genetic condition that could be tied back to the volunteers, they might face discrimination from potential employers or insurers. And it was impossible to know how future scientists might use or abuse genetic information. No one’s genome had ever been sequenced before.

But the volunteers were also informed that measures had been put in place to protect them: They would remain anonymous, and to minimize the chances that any one of them could be identified based on their unique genetic sequence, the published genome would be a patchwork, derived not from one person but stitched together from the DNA of a large number of volunteers. “If we use the blood you donate” to prepare DNA samples, the consent form read, “we expect that no more than 10% of the eventual DNA sequence will have been obtained from your DNA.”

Soon, however, those assurances began to wither. When a much-celebrated working draft of the human genome was published in 2001, the vast majority of it — nearly 75 percent — came from just one Roswell Park volunteer, an anonymous male donor known as RP11.

Leor Sapir The White House’s Transgender Tangle On youth gender medicine, the Biden administration shows that it is caught between the evidence and its activist base.

https://www.city-journal.org/article/the-white-houses-transgender-tangle

New evidence suggests that the White House is taking its marching orders on so-called gender-affirming care for kids from transgender interest groups. A messaging blunder last week revealed that the Biden administration likely knows that gender hormones and surgeries for kids are unpopular but fears that saying so will alienate the powerful organizations that support these controversial procedures.

In late June, documents released in Boe v. Marshall—a case challenging Alabama’s ban on sex-trait modification procedures for minors—revealed that the assistant secretary for health at the U.S. Department of Health and Human Services, Rachel Levine, pressured the World Professional Association of Transgender Health (WPATH) to eliminate age minimums from its latest “standards of care,” due to fear that specifying adolescent ages for surgeries would invite political backlash and result in legal restrictions on teen gender surgeries.

Even worse for a group that claims the mantle of medical science, internal emails reveal that WPATH suppressed the publication of evidence reviews that it had commissioned from researchers at Johns Hopkins University. As The Economist reported, WPATH also required the researchers to secure the organization’s approval before publishing their findings. And, according to a court document, WPATH forced the authors to add a disclaimer that they were “solely responsible for the content” of their published work.

Within days of the Alabama documents being unsealed, the White House told Fox News and the New York Times that it opposes gender surgeries for kids. It did so despite the administration’s longstanding, well-documented support for these very procedures. On July 2, 19th News, a progressive news site, published another statement that it had received from the White House. This one reiterated the Biden administration’s opposition to surgeries but added that the White House “continue[s] to support gender-affirming care for minors like mental health care and respect[s] the role of parents, families, and doctors in these decisions” (emphasis added). Notably absent was explicit support for puberty blockers and cross-sex hormones; the statement seemed to equate “gender-affirming care” with “mental health care.”

A Supreme Court Showdown Looms on Transgender Surgeries and Puberty Blockers By Dan McLaughlin

https://www.nationalreview.com/corner/a-supreme-court-showdown-looms-on-transgender-surgeries-and-puberty-blockers/?utm_source=recirc-

The Supreme Court took seven cases this morning to hear next year, including a long-running lawsuit by Holocaust survivors against Hungary for expropriation of property. The big one is United States v. Skrmetti, a Biden administration challenge on equal-protection grounds to Tennessee and Kentucky laws that restrict the use of potentially irreversible gender-transition treatments such as transgender surgeries and puberty blockers on minors.

I explained, back when the lawsuit was filed in May 2023 as part of Merrick Garland’s campaign to stamp out self-government in the states on any issue where states dissent from cultural progressivism, why it was nuts:

The legislature reached its own conclusions about whether the treatments at issue were medically supported or abusive to children. . . . Are these really interests no legislature is permitted to consider? The complaint cites the American Psychiatric Association’s Diagnostic & Statistical Manual of Mental Disorders (“DSM-V-TR”) as “an authoritative source for psychiatric conditions,” ignoring how often the DSM has been revised — and politicized — over the years. Of course, unlike the Tennessee legislature, the authors of the DSM are neither representative of, nor accountable to, a democratic populace. Moreover, on transgender issues, there is a significant divide between the American medical establishment and the European medical establishment. I’m as rah-rah USA as the next guy, but when that happens, it’s at least reasonable to allow the democratic process to consider the possibility that the Americans are wrong. Once upon a time, the American medical profession refused to accept the European consensus that doctors should wash their hands.

We may get a sense of how this Court resolves this question soon in this term’s big abortion case, Moyle v. United States, in which the Biden administration and the liberal justices argue that a federal statute puts an unelected national “medical consensus” above the elected legislatures in determining the standards for emergency-room care. Then again, Moyle is a statutory case rather than a constitutional one, and it might well be resolved on other grounds.

Medical Journal Editorial Urges Lawfare against Oil Companies: Wesley Smith

https://www.nationalreview.com/corner/medical-journal-editorial-urges-lawfare-against-oil-companies/?utm_source=recirc-desktop&utm_

Our most venerable medical journals have gone political, continually espousing the redefinition of our most contentious political controversies — race, climate change, guns, etc. — into public-health emergencies to permit the authority of medicine and people’s trust in doctors to sway outcomes.

A Perspectives editorial penned by law professors in the New England Journal of Medicine enters the fray again, this time, advocating lawfare by governments against fossil fuel industries. The authors take heart from a legal settlement between a Louisiana parish and oil companies. From, “State and Local Climate Litigation for Protecting Public Health:”

The case filed by Cameron Parish, which was settled in December 2023 for an undisclosed amount of money, was one of many that have targeted the oil industry. Louisiana communities have filed more than 40 lawsuits against oil companies over their dredging activities, alleging that the companies’ actions polluted local bodies of water and made the communities more susceptible to flooding.

How The Doctor At The Center Of Latest Texas Children’s Hospital Scandal Built An Alliance With Transgender Activists The doctor teamed up with professional transgender activists in a bid to halt a Texas law defending children from transitions. Spencer Lindquist

https://christopherrufo.com/subscribe?utm_source=email&utm_campaign=email-subscribe&r=

Dr. Richard Ogden Roberts III is a pediatric endocrinologist at the Texas Children’s Hospital who’s administered puberty blocking and cross-sex hormone medications to young patients suffering from gender dysphoria. He was also one of the plaintiffs in a lawsuit that sought to halt a ban against child sex changes, leveraging his medical credentials as he worked alongside radical activist organizations.

Now he’s found himself at the center of a new scandal at the hospital, which has been enveloped in criticism after one whistleblower exposed the hospital for lying to the public about their offerings of transgender medical interventions to children and was then targeted by the federal government as a result.

New allegations that Roberts committed Medicaid fraud have cast further doubt on his so-called “gender-affirming care” operation, with a whistleblower claiming that the hospital “is illegally billing Medicaid for transgender procedures” with the help of Roberts, who is now being investigated by Texas Attorney General Ken Paxton since the state bars the use of Medicaid funds for any and all medical interventions that seek to change people’s sex.

Roberts embodies the partnership between radical transgender ideologues and the medical establishment. A closer look at Robert’s effort to halt Texas’ ban on child sex changes indicates that the doctor formed an alliance with far-left ideologues and activist groups, many of which enjoy the backing of the pharmaceutical companies that stand to profit from transgenderism in the process.

Big News: The Surgeon General Calls for a Warning Label on Social Media Dr. Murthy is right. The evidence of widespread harm to adolescents is now strong.Jon Haidt And Zach Rausch

https://www.afterbabel.com/subscribe?utm_source=email&utm_campaign=email-subscribe&r=

The U.S. Surgeon General, Vivek Murthy, has long been a leader on the youth mental health crisis. He wrote a book in 2020 on loneliness (Together: The Healing Power of Human Connection in a Sometimes Lonely World), and in 2023 he issued a landmark report on loneliness. In 2023, he also published a major report, a Surgeon General’s Advisory reviewing the research on social media and concluding that:

The current body of evidence indicates that while social media may have benefits for some children and adolescents, there are ample indicators that social media can also have a profound risk of harm to the mental health and well-being of children and adolescents.

Yesterday, June 17, Dr. Murthy dropped a bomb: An essay in the New York Times in which he called for government-mandated warning labels on social media, akin to those that a previous Surgeon General called for in 1964, on cigarettes.

The Murky Business of Transgender Medicine: Christopher Rufo

https://www.city-journal.org/article/the-murky-business-of-transgender-medicine
The “gender-affirming care” business has always had an aura of madness around it. Wielding the authority of white coats and prestigious degrees, doctors have convinced large swaths of the public that some children are “born in the wrong body.” The solution? Stop puberty, prescribe cross-sex hormones, and then, with the stroke of a knife, remove body parts—most commonly breasts, less frequently genitalia.

These medical practices use scientific rhetoric to affirm what is, at bottom, an ideological program. And gender activists have been successful enough at capturing the legitimizing institutions—medical societies, regulatory bodies, and teaching hospitals—to repel most challenges to the burgeoning child sex-change industry. 

Now, though, the consensus appears to be shifting. European governments have backed away from many of these dubious procedures. In England, the Cass Review has raised grave questions about the scientific evidence behind “gender-affirming care.” In the United States, the public has turned decisively against the use of puberty blockers and gender surgeries on minors, with some state legislatures banning the practice. 

I have reported on one of these programs, the pediatric gender clinic at Texas Children’s Hospital. Last year, I published an investigation demonstrating that, though it had promised to shut down its program, Texas Children’s had continued to administer hormone drugs to children as young as 11. Following the story, the state attorney general launched an investigation, and state legislators passed a bill, SB 14, prohibiting all transgender medical interventions on minors.

While these scandals caught the headlines, another story involving the same institution was brewing in the background: medical fraud. 

According to a new whistleblower, doctors at Texas Children’s Hospital were willing to falsify medical records and break the law to keep practicing “gender-affirming care.” Caught in the wave of ideological fervor, two of the hospital’s prominent physicians, Richard Ogden Roberts and David Paul, cut corners and, according to the whistleblower, committed Medicaid fraud to secure funds for the hospital’s child sex-change program.

(Texas Children’s Hospital, Roberts, and Paul did not respond to a request for comment.)

This is a story of fanaticism, hubris, and the murky business of transgender medicine. It would have remained hidden, except for the courage of two people inside the hospital, a surgeon named Eithan Haim and a nurse who has now decided to come forward. Both have risked much to alert the public to the barbarism that is occurring at the nation’s largest, and arguably most prestigious, children’s hospital.

The American College of Pediatricians just put out a statement calling out all the major medical associations by name for pushing the gender transition craze on kids.

https://doctorsprotectingchildren.org

The American College of Pediatricians just put out a statement calling out all the major medical associations by name for pushing the gender transition craze on kids. They ask for these groups to “IMMEDIATELY stop the promotion of social affirmation, puberty blockers, cross-sex hormones and surgeries for children and adolescents who experience distress over their biological sex.” The full statement
“Therefore, given the recent research and the revelations of the harmful approach advocated by WPATH and its followers in the United States, we, the undersigned, call upon the medical professional organizations of the United States, including the American Academy of Pediatrics, the  Endocrine Society, the Pediatric Endocrine Society, American Medical Association, the American Psychological Association, and the American Academy of Child and Adolescent Psychiatry to follow the science and their European professional colleagues and immediately stop the promotion of social affirmation, puberty blockers, cross-sex hormones and surgeries for children and adolescents who experience distress over their biological sex.  Instead, these organizations should recommend comprehensive evaluations and therapies aimed at identifying and addressing underlying psychological co-morbidities and neurodiversity that often predispose to and accompany gender dysphoria. We also encourage the physicians who are members of these professional organizations to contact their leadership and urge them to adhere to the evidence-based research now available.” They link to MANY studies on their site:

Anthony Fauci has made a mockery of science America’s Covid doctor discounted all the evidence against social distancing and lockdowns. Cory Franklin

https://www.spiked-online.com/2024/06/06/anthony-fauci-has-made-a-mockery-of-science/

In Uncontrolled Spread, Scott Gottlieb, former US Food and Drug Administration commissioner, observed that the six-foot social-distancing rule was ‘probably the single most costly intervention’ recommended by the US Centers for Disease Control and Prevention (CDC) that ‘was consistently applied throughout the pandemic’.

You might have expected such a significant intervention to have had a strong evidential basis. Yet in remarks made in January before the US Congress, though only made public last month, Dr Anthony Fauci, the lead Covid-19 adviser to Donald Trump and Joe Biden, described how the social-distancing recommendation came about:

‘It sort of just appeared. I don’t recall, like, a discussion of whether it should be five or six or whatever. I was not aware of studies that in fact [supported the six-foot recommendation]. That would be a very difficult study to do. I think it would fall under the category of empiric. Just an empiric decision that wasn’t based on data or even data that could be accomplished.’

This was a curious admission coming from the man who described himself last year as ‘fundamentally about science’. In 2022, he said in an interview with a medical journal:

‘There are, in many respects, people who have complete disregard for facts, or distort facts, distort reality, deny data and make statements that are not at all backed by scientific information. What scientists have to do is just stick with the science and stick with the data. It is very frustrating when you’re dealing with individuals, institutions or groups that actually deny the reality or make statements that are not backed by facts. You can’t get rattled; just make sure you stick with the science.’

But did Fauci ‘stick with the science’? Of course not.

A New Medical Coalition Rebuts the Propriety of ‘Gender-Affirming Care ’By Wesley J. Smith

https://www.nationalreview.com/corner/a-new-medical-coalition-rebuts-the-propriety-of-gender-affirming-care/?utm_source=recirc-desktop&utm_

It took too many years, but finally some countries in Europe are pushing back against so-called gender-affirming care that promotes irreversible body-altering interventions to gender-confused children and adolescents. Meanwhile, the thoroughly researched and soberly written Cass Review — authored by a highly respected pediatrician from the U.K. — exposed how evidence supporting the benefits of such drastic measures is scant while the potential harm is demonstrable. There’s no question that, in Europe at least, the tide has turned.

But not here. For some reason — ideology, politics, hubris — the American medical establishment (except for the American Academy of Pediatrics, which has agreed to re-review the data) has barely acknowledged these newest scientific studies and reforms. Neither has the Biden administration.

But now, a new American medical coalition — Doctors Protecting Children — has organized to fight back against the ideological thrall and to restore a more rational and efficacious standard of care for children. It has just issued the Doctors Protecting Children Declaration — authored by the American College of Pediatricians (not to be confused with the AAP) — setting forth specifics. (Full disclosure: My think tank, the Discovery Institute, supports the declaration.)