https://www.acsh.org/news/2021/06/10/covid-19-vaccines-will-not-be-enough-we-also-need-effective-treatments-15596
The COVID-19 vaccines have been nothing short of miraculous. Life is returning to normal in many places. But ACSH advisor Dr. Henry Miller argues that we will still need effective medical treatments for COVID-19.
COVID-19 vaccines are the miracle that has significantly suppressed the pandemic in a number of countries, including the United States, where the current seven-day moving averages of cases and deaths are at levels not seen since March of 2020. With continued aggressive vaccination, we can further suppress the numbers – getting us closer to pre-pandemic “normality.”
However, for several reasons, vaccines alone won’t be the whole solution.
First, in spite of the overwhelming and growing evidence of the importance, safety, and efficacy of the vaccines, there remains a core of the population who will refuse them.
Second, millions of Americans are taking immunosuppressive drugs — for cancer or autoimmune diseases, for example — that may attenuate the effect of the COVID-19 vaccines. A study by researchers at the Johns Hopkins University School of Medicine of more than 650 organ recipients — who take drugs to suppress their immune system to prevent rejection of their transplanted organs – found that 46 percent had no antibody response after two doses of the Pfizer-BioNTech or Moderna vaccines. In another study, a large group of academic researchers found that patients with conditions such as lupus, psoriasis and inflammatory bowel disease who were taking two types of drugs — glucocorticoids and B cell depleting agents — had a substantially impaired immune response to the Pfizer-BioNTech and Moderna vaccines.
Third, the proliferation of “variants of concern” – mutants of the original Wuhan strain of SARS-CoV-2 that are highly transmissible and may exhibit immune evasiveness in vaccinated subjects — in the future will likely compromise to some degree the efficacy of the currently available vaccines. Increasing the likelihood of this outcome are the continuing significant outbreaks of COVID-19 in many of the world’s low- and middle-income countries, which provide opportunities for new, opportunistic mutants to emerge.
Fourth, in view of the above, the best-case scenario is probably that COVID-19 will not in the foreseeable future completely disappear but will become endemic like influenza virus and the coronaviruses that can cause the common cold. In order to save lives and modulate the severity of future COVID-19 infections, it will be critical to develop safe and effective treatments in addition to vaccines.